FLT3 and acute myeloid leukemia: As shown in Fig. 1B, three AML cell lines including MV-4-11, MOLM-13 and Kasumi-6, and one AML-PDX, AM7577, carry FLT3-ITD mutations1, whereas the remaining 3 AML-PDX models including AM8096, AM7407 and AM5512 have wild-type FLT3.