FLT3 and acute myeloid leukemia: Autoactivation of FLT3 independent of its ligand (FL) interaction is usually associated with internal tandem duplications (ITDs) within the juxtamembrane domain or point mutations in the kinase domain activation loop (TKD: tyrosine kinase domain) and has been demonstrated to be one of the key leukemogenic drivers found in one-third of AML patients.