In addition, AML patients with inversion of chromosome 16 [inv(16)(p13q22)] which results in the fusion transcript CBFb-MYH11 showed upregulated expression of CSF1R and disruption of the CSF1R signaling via a CSF1R inhibitor significantly reduced inv(16) AML tumor growth16. The gene discussed is CBFB; the disease is acute myeloid leukemia.