The results of the univariate Cox regression models showed that older age; a history of hypertension; a history of ischemic heart disease; higher levels of SBP, HbA1c, SCr, urea, and potassium; lower levels of DBP, eGFR, ALT, and albumin; and the use of diuretics, ACEIs, ARBs, beta-blockers, calcium channel blockers, insulin, and high intensity statins increased the risk of developing stage 3–5 CKD. This evidence concerns the gene INS and Hypertension.