After adjusting for confounding factors, such as maternal age, duration of infertility, anti-Müllerian hormone (AMH), follicle stimulating hormone (FSH), frozen time, fertilization method, endometrium thickness, blastocyst quality, and D3 cell number, we observed that blastocyst quality and D3 cell number were independently associated with the LBR. Here, BRD2 is linked to Infertility.