REST and epilepsy: The principal findings of these experiments are as follows: (1) SE augments REST/NRSF chromatin binding, and it is possible to block this increase using NRSE-ODNs that are well tolerated; (2) transient reduction of REST/NRSF chromatin binding increases the latency to the first spontaneous seizure in the epileptogenic process triggered by SE; and (3) acute KA-SE–induced increase of REST/NRSF binding to the chromatin is not required for the consequent epilepsy, although it may accelerate epileptogenesis and increase the overall seizure burden.