IL17A and cancer: Furthermore, the KEGG pathways of up-regulated proteins were significantly enriched in IL-17 signaling pathway (p = 2.85E-04) and transcriptional misregulation in cancer (p = 4.61E-04) (Fig. 3I), while the pathways of downregulated proteins were significantly enriched in peroxisome (p = 4.25E-06) and tryptophan metabolism (p = 1.29E-04).