Together, results from our preclinical study using the in vivo mouse model (Fig. 6, A–F) agree with the above in vitro cell lines studies and demonstrated that targeting ERβ could suppress ccRCC metastasis via regulation of the LncRNA-SERB/ERβ/ZEB1 signals (Fig. 7). This evidence concerns the gene ESR2 and nonpapillary renal cell carcinoma.