Consistently, the results of metastasis foci (as seen in the spleen, right kidney, lung, liver, and heart) also showed a similar conclusion that LncRNA-SERB increased the ccRCC metastasis (Fig. 6C) and the inclusion of sh-ERβ can partly block/reverse the oe- LncRNA-SERB -increased ccRCC metastasis, including the number of metastasis foci (Fig. 6, D and E). This evidence concerns the gene ESR2 and nonpapillary renal cell carcinoma.