In RA, CD4+ T cells play a crucial role in inflammatory responses affecting the synovial tissue of joints by producing inflammatory cytokines and assisting B cells to produce antibodies.[1,19] CD4+ T cells preferentially accumulate in a perivascular distribution and are elevated in the synovium in RA,[20] partly due to the interaction of chemokines and chemokine receptors.[3,5] Therefore, it is necessary to determine whether the disease activity of RA and inflammatory cytokines are associated with the expression of certain chemokine receptors on CD4+ T cells. This evidence concerns the gene CD4 and rheumatoid arthritis.