In the myeloid cell subset, CD33 on CD33br HLA DR+ CD14dim (OR = 1.049, 95% CI = 1.005–1.096, P = .029) and Monocyte CX3CR1 on CD14− CD16− (OR = 1.065, 95% CI = 1.003–1.131, P = .039), as well as HVEM on CD4+ (OR = 1.098, 95% CI = 1.017–1.186, P = .017) in mature T cells and CD11c+ monocyte %monocyte (OR = 1.148, 95% CI = 1.034–1.275, P = .009) in cDCs, were also positively correlated with an increased risk of PC. The gene discussed is CD4; the disease is pachyonychia congenita.