Notably, phenotypes such as CD4+ CD8dim %leukocyte (OR = 0.852, 95% CI = 0.729–0.995, P = .0430) and HLA DR+ CD4+ AC (OR = 0.933, 95% CI = 0.883–0.986) in TBNK were inversely correlated with PC risk. This evidence concerns the gene CD4 and pachyonychia congenita.