Atrophic gastritis can cause hyperhomocysteinemia, an independent risk factor for atherosclerosis.[8] The 2 conditions include overlapping inflammatory environmental factors, including IL1B,[11,12] IL1RN,[13,14] PTGS2,[15,16] IL1A,[17,18] MUC1,[19–21] IL10,[22–24] S100A8,[25,26] and GSTM1.[27,28] In addition, multiple signaling pathways are involved in both diseases. This evidence concerns the gene S100A8 and atherosclerosis.