To further validate our findings, we analyzed the correlation between 4 hub genes (C3, PTGIR, CX3CL1, and PTHLH) and immune cell infiltration in asthma, This result indicates that C3, PTGIR, CX3CL1, and PTHLH expression were significantly correlated with the infiltration of immune cells (Fig. 8E). Here, C3 is linked to asthma.