Rare variants in the AGT gene are a major cause of asthma susceptibility in African Americans.[34] PTHLH is a gastrin-regulated growth factor that aids in maintaining gastric epithelial homeostasis and also promotes the epithelial mesenchymal transition of intestinal epithelial cells.[35,36] Interestingly, some scholars have postulated[37] that the intestine is a key site for the development of immune cells, and studying the interactions between the gut microbiota and immune cells can provide potential targets for the treatment of asthma. The gene discussed is PTHLH; the disease is asthma.