The Cox multivariable regression analysis showed that SIRI level was associated with the overall survival and was superior to AFP level or Child-Pugh score in predicting the overall survival.[28] Among breast cancer patients receiving chemotherapy, cases with SIRI ≥ 1.8 × 109/L had shorter time to progression and shorter overall survival than patients with SIRI < 1.8 × 109/L. This evidence concerns the gene AFP and breast carcinoma.