We also observed trait-specific patterns of such sequence class enrichment, such as ‘CEBPB-binding site’ (Insomnia: OR = 5.25, p = 0.01) and ‘FOXA1/AR/ESR1-binding site’ (intelligence: OR = 4.69, p = 0.01, Figure 2 and Supplementary file 1f). The gene discussed is ESR1; the disease is insomnia.