Of approximately 2.3 million women worldwide diagnosed with BC each year,31 5% to 6% have hereditary gene PVs, with BRCA PVs being dominant, accounting for approximately half of BC with hereditary PVs.32,33 PVs in BRCA1 and BRCA2 genes were discovered in 199434 and 1995,35 respectively, and both genes encode tumor suppression proteins directly linked to homologous recombination repair of DNA.36 The risk of developing BC is approximately 72% for BRCA1 and 69% for BRCA2 PV carriers,37 while in the general population, the lifetime risk of developing BC is 13%. The gene discussed is BRCA1; the disease is breast cancer.