TGFB1 and heart disorder: Interestingly, the expression of circZFPM2 in other in vivo and in vitro cardiac disease models such as myocardial infarction (MI), hypoxia exposed NRCMs or TGFβ treated human cardiac fibroblasts, remained unchanged, suggesting HCM-specific regulation of this circRNA candidate (Supplementary Figure S2 A–C).