AURKA and lung carcinoma: Interestingly, besides the regulating directly relevant signaling targets in KRAS-mutated lung cancers, additional functions of AURKA continue to be identified, and include roles in DNA replication and repair (62, 63), hypoxia signaling (64), and other metabolic processes (65, 66); it is likely that these roles also contribute to supporting malignant growth, and merit further investigation.