Indeed, IL‐17RA signaling involves in the pathogenesis of UC and has been linked to promote the expression of pro‐inflammatory cytokines (including IL‐1β, IL‐6, and TNF‐α etc) and chemokines (such as CXCL1, CCL2, CXCL2, and CCL20 etc), as well as lead to intestinal barrier disruption.[12, 33] Consistently, in this study, the correlation analysis results showed that IL‐17RA signaling key genes were correlated with colitis clinic features, inflammation and intestinal barrier, which revealed that IL‐17RA signaling play a vital role in the development of UC. This evidence concerns the gene TNF and colitis.