TNF and colorectal carcinoma: The abnormal change of intestinal barrier can cause the aggressive behavior of intestinal immunity, and further lead to a large release of pro‐inflammatory factors including IL‐1β, IL‐6, and TNF‐α to aggravate colon injury.[48] Indeed, in UC, the severe inflammatory responses in colon tissue are significantly negatively correlated with intestinal barrier function and increased the risk of CRC.