Meanwhile, corr_heatmap analysis also showed that the expression of IL‐17RA, Act1, and TRAF6 proteins have strong negative correlation with body weight, colon length, ZO‐1, Occludin and Muc‐2 in colitis mice, and a significant positive correlation with DAI score, histopathological score and pro‐inflammatory cytokines (Figure S3B, Supporting Information). This evidence concerns the gene TRAF3IP2 and colitis.