APS pathogenesis is partly orchestrated by epigenetic aberrance.[6, 27] Monocytes play a key role in aPLs‐mediated APS pathogenesis by upregulating TF, vascular cell adhesion molecule‐1 (VCAM‐1), IL‐6, IL‐8, and TNF‐α expression.[13, 28] Accumulating evidence suggests the therapeutic potential of epigenetics targeting monocytes. The gene discussed is TNF; the disease is autoimmune polyendocrinopathy.