ATG5 and autoimmune polyendocrinopathy: Monocyte‐macrophage autophagy is linked to inflammation and thrombosis, and its dysfunction is a feature of autoimmune activation.[45] In a previous study, impaired autophagy was detected in in a murine APS model.[23] In the in vivo and in vitro APS models of our study, we tested downregulated LC3II/I, Beclin‐1, and ATG5 and upregulated p62/SQTM1, indicating a deficiency of autophagy.