A previous study reported that propofol could reverse anhedonia by inhibiting dopamine transporters.[4a] Additionally, clinical studies have suggested that propofol can alleviate perioperative anxiety by inhibiting the activation of the hypothalamic–pituitary–adrenal (HPA) axis to maintain the homeostasis.[5] However, whether propofol can alleviate pain‐associated anxiety responses has not yet been determined, and its neural mechanisms and molecular targets have not yet been investigated. Here, SLC6A3 is linked to Anxiety.