The reduction or loss of G3BP2 expression contributes to induce EMT and promote breast tumor metastasis.[42, 43] In contrast to its intensive role in tumor development, numerous studies have shown that the upregulation of G3BP2 is significantly correlated with unfavorable outcomes in colorectal cancer and esophageal squamous cell cancer.[44, 45] However, the function and underlying molecular mechanisms of action of G3BP2 in HCC metastasis remain largely unknown. This evidence concerns the gene G3BP2 and hepatocellular carcinoma.