G3BP2 belongs to the G3BP protein family and has conventionally been regarded as a key component of stress granules.[39] G3BPs are found in many types of different cancers and participate in regulating various tumor initiation and progression‐related signaling pathways, such as Ras, mTOR, NF‐κB, and EMT signaling pathways.[40, 41, 42] Although mounting evidence has revealed the critical role of G3BPs in the pathology of various tumors, the role of G3BP2 in cancer growth and metastasis remains controversial. This evidence concerns the gene G3BP2 and neoplasm.