In this study, we demonstrated that PEPT1 was upregulated in HCC and mediated the transport of dipeptides to enhance the epithelial and mesenchymal transformation of tumor cells by inducing MAP4K4‐dependent G3BP2 phosphorylation, thereby sustaining the survival of tumor cells and facilitating HCC metastasis (Figure 9I). Here, SLC15A1 is linked to hepatocellular carcinoma.