Inspired by the recent development of using exosomes to deliver therapeutic cargos for cancer therapy, we constructed RGD or M2pep‐decorated and si‐MALAT1‐encapsulated exosomes (RGD; M2pep‐293T‐EX‐SI‐1) and used the engineered exosomes to target gastric cancer cells and M2 TAMs simultaneously in mouse tumor models. This evidence concerns the gene MALAT1 and gastric cancer.