Our findings are consistent with two previous studies that explored the function of M2 TAM exosomes in cancer metastasis and chemoresistance, in which MALAT1 was also identified to be upregulated in M2 TAM exosomes.[12, 13] Our study further uncovered the biological roles of MALAT1 upregulation in M2 TAM exosomes and elucidated the underlying mechanisms, adding new information for understanding the interplay between TAMs and tumor cells in the TME and suggesting an important role of exosomal lncRNAs from TME cells in promoting cancer progression. The gene discussed is MALAT1; the disease is cancer.