Exosomes modulate the reciprocal interaction between tumor cells and non‐tumor cells in the TME to promote cancer progression.[8] In this study, we reported that M2 TAMs promoted the growth, metastasis, and chemoresistance of gastric cancer in vitro and in vivo via exosomal MALAT1, a canonical oncogenic lncRNA. The gene discussed is MALAT1; the disease is cancer.