COL1A1, COL1A2, COL11A1, and COL5A1 have been reported to regulate several cancers, including colorectal cancer, esophageal cancer, hepatocellular carcinoma, renal cell carcinoma, breast cancer, and gliomas.59, 60, 61, 62, 63. This evidence concerns the gene COL1A2 and esophageal cancer.