COL1A1, COL1A2, COL11A1, and COL5A1 have been reported to regulate several cancers, including colorectal cancer, esophageal cancer, hepatocellular carcinoma, renal cell carcinoma, breast cancer, and gliomas.59, 60, 61, 62, 63. The gene discussed is COL5A1; the disease is breast cancer.