COL1A1, COL1A2, COL11A1, and COL5A1 have been reported to regulate several cancers, including colorectal cancer, esophageal cancer, hepatocellular carcinoma, renal cell carcinoma, breast cancer, and gliomas.59, 60, 61, 62, 63. Here, COL5A1 is linked to central nervous system cancer.