PPARA and hepatocellular carcinoma: Concomitant with the cellular phenotype change was an abnormal expression of a series of proteins associated with metabolic and PPAR pathways such as APOA1, APOA2, etc. Nevertheless, this study had the following limitations: It was an exploratory study restricted to HepG2 cells, so future research on the regulation of HCC by GRK4 will require the use of expanded hepatoma cell lines.