Concomitant with the cellular phenotype change was an abnormal expression of a series of proteins associated with metabolic and PPAR pathways such as APOA1, APOA2, etc. Nevertheless, this study had the following limitations: It was an exploratory study restricted to HepG2 cells, so future research on the regulation of HCC by GRK4 will require the use of expanded hepatoma cell lines. Here, GRK4 is linked to hepatocellular carcinoma.