KCNN4 and cancer: For example, activation of KCa3.1 channels by 1-EBIO restored the ability of cancer-derived CD8+ T cells to chemotax in the presence of adenosine (Chimote et al., 2018) and rescued T cell function in vitro in high extracellular [K+] that is characteristic to the TME (Eil et al., 2016).