Decreased the number of activated T cells, B cells, and neutrophils in BALF, lung tissue, mesenteric lymph nodes, and peripheral blood mononuclear cells; reduced the secretion of cytokines in BALF and downregulated the expression of proinflammatory cytokines MUC5AC, transient receptor potential vanilloid receptor 1 and transient receptor potential ankyrin 1 in COPD mice’s lung tissue. Here, MUC5AC is linked to chronic obstructive pulmonary disease.