In turn, cytotoxic CD8+ T-cell lymphomas of skin, particularly the primary cutaneous, aggressive and epidermotropic cytotoxic T-cell lymphoma (PCAECyTCL) show alterations of predominantly JAK2 but also JAK3, STAT5B, and SOCS1 genes, among other genomic changes (52, 53). The gene discussed is JAK2; the disease is T-cell non-Hodgkin lymphoma.