SCs have been shown to endorse the epithelial-mesenchymal transition (EMT) and transmigration of lung cancer cells via CXCR2 by releasing chemokine CXCL5, augmenting expression of Snail and Twist, functional markers of EMT, and activating the PI3K/AKT/GSK-3β/Snail-Twist signaling pathway in lung cancer cells (Zhou et al., 2018). Here, TWIST1 is linked to lung cancer.