EBNA-1 was also shown to harbor epitopes that share similarities with myelin basic protein, the implicated autoantigen in multiple sclerosis, and with La antigen, which may trigger Sjögren’s syndrome, in addition to Sm (the small nuclear ribonucleoprotein) which may play a role in SLE (Poole et al., 2006; Kakalacheva et al., 2011; Carter, 2012). This evidence concerns the gene SSB and Sjogren syndrome.