F2 and acute kidney injury: In the overall population of critically ill dogs, the number of ODs was distributed as follows: acidemia (n = 202), hyperlactatemia (n = 152), acute kidney injury (n = 96), hyperbilirubinemia (n = 68), prolonged coagulation times (either activated partial thromboplastin time, aPTT, or prothrombin time, PT) (n = 68), thrombocytopenia (n = 64), hypoxemia (n = 41), fluid-refractory hypotension (n = 26), stupor or coma (n = 18).