Some drugs used during pregnancy are also recognized as maternal risk factors for ROP, including antihistamine, beta blockers, aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), and antibiotics.[32] Furthermore, in our study, using methyldopa, levothyroxine, insulin, and aspirin by mothers were not associated with the occurrence of ROP in their infants. This evidence concerns the gene INS and retinopathy of prematurity.