NTN1 and ischemic stroke: Besides the aging-related neurodegenerative disorders, the reduced serum netrin-1 level is also found in ischemic stroke and its complications (Guo et al., 2020; Chen Z. et al., 2022), post-stroke depression (Chen et al., 2020a), and delayed neurological sequelae in unintentional carbon monoxide poisoning (Kokulu et al., 2020); and increased serum Netrin-1 predicts better prognosis of ischemic stroke (Guo et al., 2019; Zang et al., 2021).