LGMN and Parkinson disease: Besides, deficiency of Netrin-1 activates of delta-secretase (asparagine endopeptidase, AEP) which then cleaves both α-Synuclein at N103 and the UNC5C receptor in an age-dependent manner in mice, resulting in accelerated DA neuronal loss and PD phenotypes and pathologies, which can be rescued by AEP deletion.