Normally it is expressed mainly during embryonic development, but probably due to the function of anti-apoptosis through its death receptors, Netrin-1 has been found to be highly expressed in tissues of many tumors, including inflammation-associated colorectal cancer (Paradisi et al., 2008, 2009), metastatic breast cancer (Fitamant et al., 2008), endometrial cancer (Cassier et al., 2023), lung cancer (Delloye-Bourgeois et al., 2009a), neuroblastoma (Delloye-Bourgeois et al., 2009b), lymphoma and melanoma (Broutier et al., 2016; Boussouar et al., 2020). This evidence concerns the gene NTN1 and melanoma.