MAPT and Alzheimer disease: The protein Tau has 44 phosphorylated sites and 28 of which are elevated in AD, which involves nearly 20 kinases including GSK3β (Glycogen synthase kinase-3 β), CDK5 (cyclin-dependent protein kinase-5), MAPK (mitogen-activated protein kinases), etc. (Martin et al., 2013; Tan et al., 2015; Bai et al., 2020).