In consideration that Netrin-1 is also a critical factor in Parkinson’s disease (PD) and that mutation of Netrin-1 can cause neurological disorders directly, we here summarize the genetics, pathology, biochemistry, cell biology and other evidence in research progress about Netrin-1 to provide better understanding of Netrin-1 as a promising molecular in molecular mechanism and biomarker potential in these neurodegenerative diseases. Here, NTN1 is linked to neurodegenerative disease.