Netrin-1 regulates neuronal axon guidance in human mainly through the DCC (deleted in colorectal cancer) and UNC-5 receptors (uncoordinated-5 homolog family members, UNC5A, UNC5B, UNC5C and UNC5D), and other possible receptors that include neogenin (Moore et al., 2007), DSCAM (Down syndrome cell adhesion molecule) (Ly et al., 2008; Liu et al., 2009), Adora2b (adenosine receptor A2b)(Corset et al., 2000), CD146 and integrin subunits (Stanco et al., 2009; Lemons et al., 2013; Tu et al., 2015; Li et al., 2023). Here, ADORA2B is linked to colorectal cancer.