According to the human gene mutation database (Stenson et al., 2020), other genetic variations with NTN1 are also indicated in autism spectrum disorder (A449D) (Iossifov et al., 2014), adult-onset hearing loss (T375P) (Lewis et al., 2018), intellectual disability (V429M) or hypogonadotropic hypogonadism (R362C, T525R) respectively (Bouilly et al., 2018; Hu et al., 2019), although NTN1 are not the primary mutated gene in these diseases and further validations are needed. The gene discussed is NTN1; the disease is Intellectual disability.