NFATC1 and intervertebral disk degenerative disorder: Finally, whether P2X7R can promote both a non-genomic and genomic response to mechanical stimuli in IVD cells via a signalosome with NFATc1 or lamin A/C and thus participate in the physiological and pathological homeostasis of the human IVD remains a crucial investigation that may have clinical significance for innovative therapies for patients suffering from IDD.