LARGE2 and colorectal carcinoma: In CRC, driver genes such as DACH1 (Hu et al., 2020), LARGE2 (Dietinger et al., 2020), and KIT (Küçükköse et al., 2022) were knocked out by using CRIPSR/CAS9 gene editing technology to investigate the promoting effects of intestinal stemness, cell-matrix adhesion, and phenotype switch in carcinomatosis, respectively.