While the tumors show a high molecular resemblance, adenocarcinomas in the esophagus in general had a higher number of macrophages and mMDSCs compared to tumors in the GEJ or stomach, whereas cells associated with an active anti-tumor immune response such as proliferating CD4 Th cells or CD8 T cells were more abundant in the stomach compared to the esophagus. The gene discussed is CD4; the disease is neoplasm.