CD70 and cancer: In addition, the importance of CD70 in solid tumors has become apparent, with aberrations reported in several types of cancer, including renal cell carcinoma, nasopharyngeal carcinoma, glioblastoma, melanoma, lung carcinoma, cervical carcinoma, breast carcinoma, ovarian carcinoma and mesothelioma, all of which are associated with decreased survival (70, 106–109).