The hypoxic microenvironment provided favorable conditions for tumor LYM through activation of HIF-1 (16), activation of Akt has been reported to promote tumor LYM with metastasis (17), preventing the abnormal activation of MAPK significantly reduced the density of LYM (18) and IL-17 promoted LYM by facilitating VEGFC secretion (19). The gene discussed is VEGFC; the disease is neoplasm.