NRG1 and congestive heart failure: Recombinant human NRG-1/Neucardin was used in phase II clinical trials investigating its safety and efficacy in patients with chronic heart failure in the U.S. (ClinicalTrails.gov identifier: NCT01251406), China (Chinese Clinical Trial: ChiCTR-TRC-00000414), and Australia (Australian New Zealand Clinical Trials Registry: ACTRN12607000330448).