UK-279,276 (neutrophil inhibitory factor) successfully demonstrated reduced neutrophil infiltration and infarct volume in a transient rat middle cerebral artery occlusion (MCAO) stroke model and in combination with tPA in a thromboembolic rat stroke model when administered <4 h (Jiang et al., 1998; Zhang et al., 2003). Here, PLAT is linked to stroke disorder.