A study in Italian patients with early and late onset of IHD, considered a general set of 44 CAD and/or MI high-risk SNPs, identifying four genetic variants (APOC3–482 C > T, MMP3 1,171 5A > 6A, SELE G98T, and 9p21.3 locus rs1333049 C > G) as independent predictors of early onset of IHD (24). This evidence concerns the gene APOC3 and myocardial ischemia.