GHSR and obesity due to melanocortin 4 receptor deficiency: While we and others could not detect any GHSR localization in the collecting duct (Figure 6A) there still seems to be a role for GHSR regarding ENaC stimulation in the collecting duct resulting in obesity- and angiotensin-II-mediated hypertension (Kemp et al., 2013; Kemp et al., 2014; Kemp et al., 2018).