P4HB and atherosclerosis: Considering the roles of PDIA1 in thrombus formation (Flaumenhaft et al., 2015) and vessel patency (Kim et al., 2018) and its involvement in the maintenance of VSMC differentiation (Fernandes et al., 2021), further understanding miR-204/211 modulation in atherosclerosis may help elucidate mechanisms underlying responses to atherogenic stimuli and plaque vulnerability.