P4HB and glioblastoma: Specifically, in endothelial cells under hypoxia, the upregulation of miR-210 decreases PDIA1 levels (Fasanaro et al., 2009), while in glioblastoma multiforme, the low levels of miR-210 were positively associated with PDIA1 upregulation and a chemoresistance phenotype (Lee et al., 2015).