Moreover, we cannot exclude a potential synergistic effect of the miR-204/211-PDIA1 axis with the modulation of another PDI family protein, such as PDIA15, which exerts effects similar to those of PDIA1 during response to TNFα and angiogenesis (Camargo et al., 2013), and both have been targeted in models of thrombotic diseases (Zhou et al., 2022). The gene discussed is TXNDC5; the disease is thrombotic disease.