Impaired glymphatic fluid transport resulting in the accumulation of intracellular waste products such as amyloid-β and tau aggregation is referred to as glymphopathy and may be involved in multiple pathological processes, including normal aging, Alzheimer’s disease, and iNPH (Benveniste and Nedergaard, 2022). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.