Comparable to other RNA-binding proteins, disrupting the function of TIA1 can lead to various diseases including cancer,7–9 autoimmune diseases10 and neurodegenerative disorders.11–14 Studies have demonstrated that mutations to theTIA1 gene may delay the disassembly of stress granule, resulting in insoluble and immobile stress granules, a clinical feature of ALS and FTD.6,11 Significant efforts are required to further elucidate the relationship between dysregulated RNA metabolism and ALS/FTD pathogenesis which may lead to novel therapeutic discoveries.11,15. Here, TIA1 is linked to frontotemporal dementia.