The results retained similar trends, with significantly higher global and regional amyloid burdens (both P < 0.05) and a significantly higher tau burden in the inferior temporal lobe (age-adjusted P = 0.027) and Braak III/IV ROIs (age-adjusted P = 0.028) in CAA compared with HTN-SVD (Supplementary Table 1). The gene discussed is MAPT; the disease is hypertensive disorder.