Cerebral tau pathology was significantly associated with cerebral amyloid angiopathy-related vascular markers, including cortical superficial siderosis (β = 0.12, 95% confidence interval 0.04–0.21) and cerebral amyloid angiopathy score (β = 0.12, 95% confidence interval 0.03–0.21) after adjustment for age, ApoE4 status and whole cortex amyloid load. The gene discussed is MAPT; the disease is cerebral amyloid angiopathy.