APOE and early-onset autosomal dominant Alzheimer disease: This finding is in line with a previous study that showed the CSF p-tau level is more closely associated with cSS than lobar haematoma in CAA.37 Supporting evidence from case reports also indicates higher tau PET uptakes in cortical regions affected by cSS.35,36 Kim et al.38 studied patients with CAA with memory impairment and showed patients with cSS presented with more Alzheimer’s disease-related features, including a higher APOE ε4 frequency, more severe memory dysfunction and lower hippocampal volume.