GLA and Fabry disease: Fabry disease is an X-linked lysosomal storage disorder that is caused by variants in the gene encoding alpha-galactosidase A (GLA).1 Impairment of GLA activity results in cellular accumulation of sphingolipids, mainly globotriaosylceramide (Gb3).2 The clinical phenotype spans a spectrum from classic Fabry disease, which is an age-dependent multi-organ disorder starting in early childhood, to late-onset symptom manifestation in adulthood and with often milder symptoms.