• Core part of APC, and crucial for cell proliferation during neurogenesis [91].• Functionally important partner of Microcephalin (MCPH1), a causative gene for microcephaly [92]• Identified as one of the hub genes co-expressed across Alzheimer’s disease and Major Depressive Disorder [93]. The gene discussed is APC; the disease is early-onset autosomal dominant Alzheimer disease.