SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: For example, when comparing an isogenic iPSC cell line acquired from a Dravet syndrome patient with a pathogenic variant in the SCN1A gene, increased expression of tyrosine hydroxylase and increased concentration of free dopamine in the culture medium in the patient's SCN1A cell line was confirmed.116