However, Pereno et al. reported that in human melanoma cells, intracellular IL-15/IL-15Rα binds to the transducing molecule TRAF2 and subsequently activates NF-κB, suggesting that the intracellular IL-15/IL-15Rα complex enables signal transduction through the IL-15Rα-associated molecules [60]. This evidence concerns the gene NFKB1 and melanoma.