Tumor growth curve showed VHH CD70 CAR-T cells efficiently controlled RCC growth, leading to complete remission in mice by day 28 (11C9 and 8B4 CAR-T), day 31 (2A5 CAR-T) and 5/7 mice by day 66 (9D8 CAR-T). Here, CD70 is linked to renal cell carcinoma.