As tumors form, the glycosylphosphatidylinositol-anchored cell-surface protein known as mesothelin binds MUC16 at N-glycosylation sites to promote cancer cell adhesion, leading to metastatic activation of tumors, including mesothelioma and ovarian cancer, in the pleura and peritoneum [11–13]. This evidence concerns the gene MSLN and ovarian carcinoma.