IHC staining also showed that the 8-OHdG-positive cells were increased, and Nrf2- and NQO1-positive cells were decreased in the xenograft tumor samples after Panobinostat or ML385 administration; however, the combination group showed much more 8-OHdG-positive cells, and less Nrf2- and NQO1-positive cells compared to the Panobinostat or ML385 group, respectively (Fig. 6F). The gene discussed is NQO1; the disease is neoplasm.