CYP21A2 and Hirsutism: The great majority of these patients that underwent genetic testing for CYP21A2 pathogenic variants were females with hyperandrogenism either in prepubertal or in peripubertal ages (premature pubic hair development, bone age advancement, severe acne and/or hirsutism, with or without menstrual irregularity, and complete lack of virilization with increased 17-OHP levels).