All girls with CPP and that were genetically tested at the premises of MGFT and identified to carry causative MKRN3 variants in the coding, promoter and the 5’-UTR region of the imprinted gene were initially confirmed with GnRH stimulated Luteinizing Hormone (LH) levels, and treatment was administered to them with long-acting GnRH analogue with effective regression of pubertal signs [4, 14, 16]. Here, GNRH1 is linked to central precocious puberty.